Step-by-step guide to start therapeutic whole foods plant based keto for cancer
Home Metabolic Dietary Therapy: Fasting, Keto and Functional Foods How to Start a Therapeutic Ketogenic Diet for Cancer (Step-by-Step Guide)

How to Start a Therapeutic Ketogenic Diet for Cancer (Step-by-Step Guide)

by Maggie Jones

The evidence for a ketogenic diet to fight cancer is undeniable and becoming overwhelming.

The evidence for a whole foods, plant-based diet to fight cancer is also pretty darn compelling.

Media and vocal proponents from both sides would lead you to believe you must choose one or the other but the truth is that a whole-foods, plant-based diet and therapeutic keto have more in common than they have differences and can be combined to take advantage of all the benefits.

When I was first diagnosed with stage 4, terminal lung cancer in 2018, I know I didn’t want to ignore any evidence-based therapeutic options. While pharmaceutical drugs saved my life in those early touch-and-go days, I absolutely credit my whole foods, plant-based way-of-eating – along with therapeutic fasting – with achieving complete remission a year later.

I was lucky (?) to have a strong background in “dieting” and was familiar with all the myriad flavors out there. I’d tinkered with and developed recipes for keto, vegan, paleo, gluten-free, anti-inflammatory, protein-fasting, vegetarian, pescatarian, flexatarian, and whole30 diets. When I heard keto could stop and reverse cancer growth, I knew just what to do. I’ve since tried to share this knowledge with others I realize not everyone has the same background.

So for once, instead of just writing theory, I’ve put together an actionable guide on how exactly to start “keto for cancer” – and notes on how you can do so while still taking advantage of the healing benefits of a whole foods, plant-based diet.

Important Reminder: Keto is not effective for all types of cancer and can be harmful for some (such as renal cancer). The decision to treat your cancer with ketosis should be made in partnership with your health care team based on your particular cancer and personal fitness.

This guide is comprehensive. And so it is long. I’ve divided it into multiple parts to make it easier to navigate:

Next steps:

What is Ketosis and how can it help cancer healing

Quick Refresher: What is Ketosis?

You probably already know that keto means eating low carb. You may have the misconception that it means eating a lot of bacon, egg and cheese. While limiting your diet to just protein and fat will get you into ketosis, it’s certainly not the only way — or even a very good way — of going about it.

Ketosis is a state in which your body burns ketones (made from fat) instead of glucose (sugar) for energy.

We know that cancer prefers glucose and, generally, can’t metabolize ketones. Being in ketosis therefore means cancer doesn’t have the energy to grow but your healthy cells have everything they need.

Better yet, ketones have been shown to be protective of healthy cells while having anti-cancer properties. When you remove the glucose sources from your diet, your body will start creating ketones from your stored body fat and dietary fat to fuel your muscles and brain. Over time, your body will start to metabolize fatty acids directly and fat will become the preferred fuel source. This is what the keto community calls “fat adapted.”

This is just the highest-level layman overview of ketosis and keto for cancer. There are more articles on this blog that dive into the science more deeply or, better yet, Miriam Kalamian’s actually wrote the book on Keto for Cancer which I highly recommend.


The difference between strict therapeutic Ketosis for cancer and standard nutritional ketosis

Strict Therapeutic Ketosis vs Standard Nutritional Ketosis

The difference between “therapeutic ketosis” and “nutritional ketosis” — often differentiated as “strict keto” and “standard keto” — pretty much boils down to the number of ketones floating around in your blood:

  • Over 0.5 mmol of ketones per liter of blood is considered the threshold for “being in ketosis.” At this number, you know that your body doesn’t have quite enough glucose to fuel its energy needs and is now converting fat into ketones to use as energy.
  • A little higher, between 1.5-3.0 ketones is considered moderate ketosis. This is the optimal zone for weight loss and other applications. For therapeutic purposes, we want to go still higher.
  • 3.0 and higher is considered therapeutic ketosis although I prefer 4.0 or above.

More important than your ketone number, however, is your GKI. GKI, or Glucose-Ketone Index, is the ratio of glucose to ketones in your blood. See this article for a complete guide too GKI.

The quick summary is that, based on research from Dr. Thomas Seyfried at University of Boston, you want more ketones than glucose in your blood. This translates to a GKI less than 1.0. Note that this is extremely difficult to achieve without some fasting or strict carb and protein restriction. A GKI less than 3.0 can still be therapeutic but, overall, the lower the better.

How to calculate GKI and what do the results mean

My personal approach is to fast at the beginning of the week to reset my GKI below 1.0 and then practice intermittent fasting while eating whole food, plant-based meals according to my macro limits for the rest of the week. The weekend before my next fast begins is an opportunity to indulge in healing foods that raise my GKI a bit – organic fruit, wild-caught salmon, pasture-raised egg, starchy vegetables – before I reset with the weekly fast. This approach ensures I eat a balanced, wide variety of foods, avoid feeling deprived, and keep my GKI in the therapeutic sub-1.0 range as much and as long as possible.


Keto diet myths and valid concerns about side effects before starting keto for cancer

Myths and Concerns around Starting Keto for Cancer

While at its roots Keto is a medical protocol, it’s become popularized for its fast weight-loss benefits. The price of being popular is that there’s a lot of misinformation out in the interwebs.

Myth: Keto is a fad diet
The number one myth, I think, is that keto has not yet been proven as an effective therapy. It has been used by doctors to successfully treat epilepsy in children since the 1920s. On the cancer front, while the research is new the results are already overwhelming. See this article here if you want a quick summary of some of the trials. Keep in mind, too, that there aren’t any pharma dollars behind diet change.

Myth: Keto is too hard
The side effects of my drugs, radiation sickness, the post-treatment radiation necrosis in my brain, being unable to breath as I drowned in my cancerous lung fluid… these things were hard. Eating delicious, nourishing food is the opposite of that.

Sidenote: I have tremendous respect for Dr. Michael Greger but in his video reviewing keto diets he asks, “Why keto when you can chemo?” My response: “!?!?!?!?!” As someone who has done both, I much prefer eating a delicious salad to injecting myself with actual poison. Also, this study showing 60% survival with chemo only, 100% survival with chemo+keto.

While there is some work required to achieve therapeutic ketosis, hopefully this article helps simplify things a bit.

Concern: What about the keto flu?
“Keto flu” is what the internet calls symptoms like headache, bodyache, insomnia, nausea, constipation, diarrhea or other flu-like symptoms that some might experience when first transitioning from glucose to ketones.

The only time you will experience anything like “keto flu” is if you’re deeply sugar dependent (eat a lot of processed foods and sweets) AND don’t drink enough water and electrolytes during the transition.

In addition to the glucose circulating in your blood after your last meal, your body stores excess glucose in the form of glucagon in your liver and muscles. Every molecule of glucagon is bound with 3-4 molecules of water. As you adapt from a sugar-fueled, cancer-feeding machine to a fat-burning, cancer-killing one, your body will burn through these stores and release the water. That, in addition to other metabolic changes in your body, means you will be losing electrolytes.

When adapting to a keto diet, you absolutely need to drink more water and possibly supplement with potassium, sodium, and magnesium. If you find you are experiencing symptoms of dehydration or “keto flu”, drink more water and consider the snake juice recipe here.

Myth: Ketosis is dangerous
Most of the real dangers of a ketogenic diet (possible increased uric acid build-up for those who suffer kidney stones, exacerbating kidney issues due to excess protein) are only relevant for a high-protein or meat-centered diet. Therapeutic levels of ketosis require protein modulation and very few animal products which eliminates these risks. Even so, it’s important to talk with your health care team about your specific case.

Some people (tragically some doctors even) confuse dietary ketosis with diabetic ketoacidosis. The first one has been proven therapeutic for epilepsy, cancer, Alzheimer’s, Parkinson’s. traumatic brain injury and more; the second one can kill Type 1 diabetics. Ketoacidosis is when ketones are elevated AND blood glucose is also elevated. In dietary ketosis, ketones are elevated because blood glucose is low. Too low for cancer to thrive.

While Type 1 diabetics and those pursuing light, nutritional ketosis can rely on inexpensive urine strips to give an indication of their ketone levels, those pursuing therapeutic ketosis need to be able to test their blood. Which brings us to…


The three tools you must have to start therapeutic keto for cancer

The 3 Tools You Need to Start Therapeutic Keto for Cancer

These are the three non-negotiable, must-haves to reap the full benefits of keto for cancer.

1. A blood and glucose monitor – ~$50 plus $100 in strips

I use the keto mojo and love it. There are other ketone meters out there but keep in mind that you will need both a ketone and glucose meter. The keto mojo combines both in one device although you still have to buy separate strips. I also heard that they’ll be incorporating automatic GKI calculation in a future model.

You’ll test a lot in the first month – maybe 70 times. Then once or twice a day the next few months. By month 4 you should only need to test a couple of times a week to make sure there are no surprises. By month 6, you’ll pretty much only need to test if you introduce something new.

2. A Cronometer.com account – free

You need to track everything you eat, there is no getting around that. (- Unless you’re going to follow my meal plan without variation and I wouldn’t wish that on anyone.) I’ve used food tracking apps for almost 20 years including MyPlate (I worked for the company that developed it), CalorieCount (now defunct), and MyFitnessPal. Cronometer leaves them all in the dust. It’s so much better that I left behind over a decade of tracking data to make the switch. I even pay for the advance features. But you don’t have to.

Just visit cronometer.com and sign up, then download the app for free. If you use my workflow, you’ll end up using both desktop and app versions.

And don’t worry, you won’t need to track for the rest of your life; just until you’ve become familiar with deep therapeutic ketosis and know exactly how to stay there.

Before starting a program of therapeutic ketosis, set up a cronometer account - it will help you achieve optimal GKI levels

3. A food scale – ~$15

In order to accurately track your food and understand its impact on your individual metabolism, you must weigh and measure. Everything. Weighing is easier and more reliable than measuring once you have your workflow set up, below.

Like cronometer, you won’t need to do this forever. I can legit tell you right now whether those 2 Brazil nuts are 7 or 8 grams and the weight of that avocado meat within 5 grams, just by eyebballing. You get to know the foods you eat regularly pretty fast.

But you still need a scale.

Simple and cheap works great. I’ve been using one like this for 2 decades now. I’ve only had to replace it once after an accidental drowning in the dishwasher.


Step-by-step guide to get started with therapeutic keto for cancer to maintain gki less than 1

The 3 Steps to Get Started with Keto for Cancer

Once you’ve assembled these tools, follow the steps below and you’ll be ready to start within the hour.

1. Calculate your keto for cancer macros

“Macros” refers to the macronutrients fat, protein and carbohydrate. Your ketogenic diet will have different daily limits for each that you will need to follow. Every individual has different requirements but you can calculate a good general starting point based on your weight and height, then refine based on how quickly and deeply you get into ketosis.

First I talk about how to calculate macros manually and the rationale behind each. Don’t worry if this is overwhelming! It’s definitely easier to calculate these automatically in Cronometer. If you don’t want to details, feel free to jump straight to how to calculate your macros in Cronometer.

Calculate macros manually

Calculate carbohydrates
First a note that when we talk about carbohydrates, or “carbs,” we’re talking about carbs exclusive of fiber and sugar alcohols. This is the standard definition of carbohydrate used on food packaging in Europe, Australia and New Zealand. In the US, food packaging includes fiber in the carbohydrate count so, in the US, consider carbs as “net carbs” or grams of carbohydrate minus grams of fiber.

The generally accepted threshold for achieving ketosis is no more than 20g net carbohydrates, or “20 carbs” per day. However, if you are eating a truly whole food, plant-based diet you will be able to get away with more. In this case, 30g is a good starting point. You will adjust this higher or lower over time to eat as many carbs as your body can while maintaining optimal GKI. In my case, it can be as high as 40-50+.

  • Carbohydrate starting limit = 30g net carbs (20 if not exclusively whole foods plant-based)

Calculate protein
Those pursuing keto for non-medical reasons like weight loss, metal clarity, or other benefits do not need to limit protein. For those pursuing the low glucose and high ketone levels therapeutic ketosis requires, protein will need to be limited. Protein beyond what your body can use immediately is converted into glucose for storage and feeding cancer cells. Too much dietary protein is the primary reason I see in people unable to achieve therapeutic ketosis.

  • Protein starting limit = your lean body weight in kg x 0.8

To calculate your lean body weight, first multiply your total body weight by your percentage body fat. Then, subtract this number from your total body weight. For example, if you’r total body weight is 65kg and you have 25% body fat, your lean body weight would be 65kg – (25%x65kg) = 48.75. You would then multiply the result by 0.8 to calculate your protein limit. In this case 39g protein. This will seem low if you’re used to eating large amounts of protein but is sufficient.

Calculate fat
Your daily calories that don’t come from fiber, net carbs, or protein will be provided by fat. Delicious, healing, nutrient-rich fats. If you are underweight, this number will be considered a target that you will want to exceed. If you have excess weight, treat this as a limit.

This number is therefore based on your basal metabolic rate, or BMR. The number of calories you naturally burn in a day. To calculate BMR you can use a calculator like this. From there:

  • Starting fat target = (Basal Metabolic Rate – (net carbs + protein) x 4) /9

I realize this is starting to get a bit complicated and, luckily, cronometer will actually do all the calculations for you

Calculate macros using Cronometer

If you’ve already set up a cronometer account (as you should have), all you need to know to calculate your macros is your age, weight, height, and percentage body fat. While you should ideally have your body fat tested, if you haven’t, you can search online for a “body fat percentage chart” for your gender to estimate.

Start in Cronometer by visiting “Settings” then clicking “Profile.” Enter your sex, birthday, weight, height, and body fat percentage. (Make sure to enter your personal information here, don’t copy mine.) No need to change the BMR or Activity Level dropdowns unless you have a truly active job like road paver or if you are underweight.

How to calculate your macros for therapeutic ketosis in Cronometer: start by adding your body details in Settings, Profile.

Next, click on “Targets.”

  1. Set “Tracking carbohydrates as” to “Net Carbs without Sugar Alcohols.”
  2. Set “Set marco targets using” to “Ketogenic Calculator.”
  3. Under the keto calculator enter the values I have here: “Custom,” “0.8” and “30” grams non-fiber carbs. (Remember, this is for whole foods, plant based keto. If you plan on eating another way, enter “20,” instead.)
How to calculate your macros (fat, carbohydrates, and protein) for therapeutic keto for cancer

You can now find your macros at the bottom of your “Diary” page. As you log food, Cronometer will show you how close you are to hitting each macronutrient target for the day and how much of your allotment remains.

2. Establish your baseline GKI and diet

Measure your blood glucose and ketones and record your baseline GKI before starting Keto for Cancer

That means pricking your finger and following your device’s instructions to get a reading for both blood sugar and ketones. Once you have the two numbers, you can calculate yourself using the formula above and record them in a safe place, or enter them into Cronometer.

In Cronometer, click “Add Biometric”

How to track GKI (glucose-ketone index) for therapeutic keto for cancer

Enter the “Ketones (Blood)” and save; then enter “Blood Glucose” and save.

How to track your glucose ketone index for therapeutic strict keto for cancer.

Cronometer will calculate your GKI and store it for comparison over time. You’ll want to test your GKI at the same time each day, once in the morning and once in the evening in the beginning, always at least 3 hours after eating, and record each measurement in Cronometer.

Overtime you’ll be able to generate reports to identify trends and understand your total time in the therapeutic GKI zone.

How to track GKI and keep it in the therapeutic range when using keto for cancer.

Establish your baseline diet and begin daily tracking

Using either the desktop of the app, record everything you ate yesterday in cronometer. Estimate amounts the best that you can and be honest. This information is only for you to get a feel for your eating and understand how it will change.

Before starting therapeutic keto for cancer therapy, record your baseline day of eating to understand impact of sugar and processed food.
A possible standard day on the Standard American Diet: 1 cup plain oatmeal, a banana and latte in the morning. Oops! Someone brought donuts but I’ll be good and only have half. A roast turkey sandwich and diet coke from Panera, fritos from the vending machine in the afternoon. Pick up a veggie burger, fries, and iced tea at Red Robin for dinner and have a scoop of ice cream before bed. Sounds pretty reasonable, right? And not too terrible? You know the answer. In addition to not containing any real food except the sugary banana and oatmeal, this day of eating provides more than twice the energy I could possibly use in the day and is the opposite of healing. There is nothing on this list I would eat on my cancer-healing diet – except the black coffee.

If you’ve eaten a lot of sugar or processed food, it may be slightly more difficult for you to enter ketosis but the benefits will be evident even sooner.

3. Make a list of the reasons you want to live a long, healthy life

If you haven’t already, make a written list of why you want to live: more time with Brad; seeing my niblings grow up– watching them choose careers and life partners; traveling to Morroco, Spain, Croatia, New Zealand; learning to play the accordion; outliving Brad so I could get a cat. These were just a few of the items on my list.

You may cry. You should cry. Crying is incredibly appropriate for those facing premature death; for those having to say an early goodbye to everything they love in the world.

Ask yourself seriously – if you could have all these things, but never eat another (–insert favorite food–), which would you choose? Heck, if you could have these things but never eat again, which would you choose?

This sounds a little dark but it was the mindset that kept me focused and committed to my diet in the early days. I knew that every hint of sugar or processed food I put into my body would make the cancer stronger. Trust me, nothing in the world tastes good enough that it’s worth making cancer stronger.

The reasons you have to live and be healthy will get you through this. No fleeting bite of food is worth the trade.


Plan and track meals to achieve deep ketosis and optimal GKI for therapeutic keto for cancer

Begin Planning and Tracking your Meals and GKI to Achieve Optimal Therapeutic Ketosis

Congratulations on taking the steps you need to get started with Keto for Cancer!

Next Up:

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8 comments

anna April 12, 2020 - 1:06 am

you are so serious in this. i may need to get this serious. Jesus take the wheel.

Reply
Maggie Jones April 12, 2020 - 9:32 am

So serious. I didn’t even cheat with an apple until I was No Evidence of Disease in October. Even now it’s whole food, plant based light keto and fasting all the time, always. I know that the crap I want to eat will just make the cancer stronger and my body weaker and I love my body too much now.

Reply
anna April 12, 2020 - 1:21 am

double dipping: this blog is just what I needed to read after writing my last blog 🙁

Reply
Maggie Jones April 12, 2020 - 9:34 am

Oof! I just caught up with you. I’m so sorry for what you’re going through. You’re totally right that getting some serious ketones flowing might be exactly what you need! Protect your poor, healthy cells while sensitizing those cancer-y ones.

Reply
seraphim August 7, 2020 - 12:36 am

Most of all — THANK YOU MAGGIE! I have been looking for just exactly this in a meal plan that was plant-based. I have been getting good GKI readings, but it has included butter, cream, etc. I cannot wait for the results I need to beat type 2 diabetes. Cancer is gone, but I don’t want it to come back, so therapeutic or better level (such as you accomplish!) is where I want to be. Plus…type 2 diabetes is a situation where our brains do not work very well and I want to correct this. Intermittent Fasting is integral.

Reply
Maggie Jones August 7, 2020 - 8:19 pm

Thank you so much for the kind words! After your miraculous cancer recovery I know you will crush Type 2 diabetes!

Reply
Rosanna Wilson October 1, 2020 - 12:44 am

Maggie please help I can’t get out of therapeutic ketosis and want to be in optimal.. my question is will I still lose weight in my current keto state? Even though I’m around 4.4 mmol??

Reply
Maggie Jones October 8, 2020 - 5:55 pm

Hi Rosanna! If you’re observing a keto diet for weight loss or other non-medical purposes, you shouldn’t need to keep your GKI in the therapeutic range. Note that GKI (glucose ketone index) and ketone measure are very different numbers. This article may help: https://cancerv.me/2019/10/25/the-complete-guide-to-glucose-ketone-index-gki-tracking-for-therapeutic-ketosis/ Blood ketones of 4.4 mmol/L are excellent for any keto application and usually indicate a very low GKI.

You should lose weight anytime you’re consuming fewer calories than you’re burning. With ketones as high as you report, you’ll almost certainly experience the appetite suppression and reduced inflammation benefits that make weight loss so much easier on keto.

Cheers!

Reply

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